Artículos de investigación

Publicado en: BMJ Open

Abortion legislation, maternal healthcare, fertility, female literacy, sanitation, violence against women and maternal deaths: a natural experiment in 32 mexican states

This natural experiment used the official maternal mortality database of the 32 Mexican federal states for a period of 10 years, to analyze the maternal mortality trend, controlling a series of independent variables that could influence it.

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Publicado en: PLOS ONE

Women’s education level, maternal health facilities, abortion legislation and maternal deaths: a natural experiment in chile from 1957 to 2007

This research evaluated the main factors related to the reduction of maternal mortality in large time series available in Chile in the context of the United Nations Millennium Development Goals (MDGs).

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Highlights

Publicado en: The Lancet, Regional Health - Americas

Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, Argentina 1980-2017

In this study, the researchers used a 38-year time series of Argentine vital records to assess the trend in cause-specific maternal mortality ratios before, during, and after the global epidemic caused by the H1N1 influenza virus in 2009.

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Publicado en: PLOS Genetics

Patagonian sheepdog: Genomic analyses trace the footprints of extinct UK herding dogs to South America

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This research concluded that the Patagonian Sheepdog (PGOD) originated from ancestral UK sheepdogs, currently being the closest link to a now-extinct population of sheepdogs from which modern herding breeds are descended.

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Publicado en: PLOS Global Public Health

Effects of emerging SARS-CoV-2 on total and cause-specific maternal mortality: A natural experiment in Chile during the peak of the outbreak, 2020–2021

A natural experiment during the peak of the SARS-CoV-2 outbreak revealed a different impact on pregnant women than previous pandemics. The study published in PLOS Global Public Health showed that it was not respiratory diseases, but other conditions that increased mortality.

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Publicado en: International Journal Of Oral Science

Host-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression

In this study, researchers analyzed the presence of bacterial proteins in samples from patients with oral cancer. They identified the presence of Fusobacterium Nucleatum, and then analyzed the protumor effects these bacteria exerted on cancer cells.

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Effects of emerging SARS-CoV-2 on total and cause-specific maternal mortality: A natural experiment in Chile during the peak of the outbreak, 2020–2021

Enriqeuz Y, Critto M, Weinberg R, De Janon L, Galleguillos A, Koch E.

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Host-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression

Muñoz-Grez C, Vidal M, Rojas T, Ferrada L, Zuñiga F, Vera A, Sanhueza S, Quiroga R, Cabrera C, Antilef B, Cartes R, Acevedo M, Fraga M, Alarcón-Zapata P, Hernández M, Salas-Burgos A, Tapia-Belmonte F, Yáñez M, Riquelme E, González W, Rivera C, Oñate A, Lamperti L, Nova-Lamperti E.

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Proteomic Analysis of the Fish Pathogen Vibrio ordalii Strain Vo-LM-18 and Its Outer Membrane Vesicles

Echeverría-Bugueño M, Hernández M, Avendaño-Herrera R.

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Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years

Garcés-Parra C, Saldivia P, Hernández M, Uribe E, Román J, Torrejón M, Gutiérrez J, Cabrera-Vives G, García-Robles M, Aguilar W, Soto M, Tarifeño-Saldivia E.

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Proteomic characterization of Tenacibaculum dicentrarchi under iron limitation reveals an upregulation of proteins related to iron oxidation and reduction metabolism, iron uptake systems and gliding motility

Avendaño-Herrera R, Echeverría-Bugueño M, Hernández M, Saldivia P, Irgang R.

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Discovery and Characterization of the ddx41 Gene in Atlantic Salmon: Evolutionary Implications, Structural Functions, and Innate Immune Responses to Piscirickettsia salmonis and Renibacterium salmoninarum Infections

Yañez A, Barrientos C, Isla A, Aguilar M, Flores-Martin S, Yuivar Y, Ojeda A, Ibieta P, Hernández M, Figueroa J, Avendaño-Herrera R, Mancilla M.

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Inorganic Polyphosphate Affects Biofilm Assembly, Capsule Formation, and Virulence of Hypervirulent ST23 Klebsiella pneumoniae

Rojas D, Marcoleta A, Gálvez-Siva M, Varas M, Díaz M, Hernández M, Vargas C, Nourdin-Galindo G, Koch E, Saldivia P, Vielma J, Gan Y-H, Chen Y, Guiliani N, Chávez F.

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Proteomic and toxicological analysis of the response of dinoflagellate Alexandrium catenella to changes in NaNO3 concentration

Saldivia P, Hernández H, Isla A, Fritz R, Varela D, M. González-Jartín J, Figueroa J, M. Botana L, Vargas C, J. Yañez A.

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Analysis of tumor-infiltrating t-cell transcriptomes reveal a unique genetic signature across different types of cancer

Vidal M, Fraga M, Llerena F, Vera A, Hernández M, Koch E, Reyes-López F, Vallejos-Vidal E, Cabrera-Vives G, Nova-Lamperti E.

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Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in pik3r1, tp53, smad4 and a potential role of the pi3k-akt and egfr pathways: a case report

Cordova-Delgado M, Pinto M, Pizarro G, Koch E, Vargas C, Hernández M, Nourdin G, Saldivia P, Rodriguez M, Berkovits A, Manque P, Rios J, Garcia-Bloj B, Garrido M.

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Patagonian sheepdog: genomic analyses trace the footprints of extinct uk herding dogs to south america

Barrios N, González-Lagos C, Dreger D, Parker H, Nourdin-Galindo G, Hogan A, Gómez M, Ostrander E.

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Derivation, internal validation, and recalibration of a cardiovascular risk score for Latin America and the Caribbean (Globorisk-LAC): A pooled analysis of cohort studies

Cohorts Consortium of Latin America and the Caribbean (CC-LAC).

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Impact of emerging virus pandemics on cause-specific maternal mortality time series: a population-based natural experiment using national vital statistics, argentina 1980-2017

Critto M, Enriquez Y, Bravo M, de Janon L, Weinberg R, Etchegaray A, Koch E.

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Proteomic analysis reveals renibacterium salmoninarum grown under iron-limited conditions induces iron uptake mechanisms and overproduction of the 57-kda protein

Avendaño-Herrera R, Saldivia P, Bethke J, Vargas C, Hernández M.

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Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies

Cohorts Consortium of Latin America and the Caribbean (CC-LAC).

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Immunomodulation of t helper cells by tumor microenvironment in oral cancer is associated with ccr8 expressions and rapid membrane vitamin d signaling pathway

Fraga M, Yáñez M, Sherman M, Llerena F, Hernandez M, Nourdin G, Álvarez F, Urrizola J, Rivera C, Lamperti L, Nova L, Castro S, Zambrano O, Cifuentes A, Campos L, Moya S, Pastor J, Nuñez M, Gatica J, Figueroa J, Zúñiga F, Salomón C, Cerda G, Puentes R, Labarca G, Vidal M, McGregor R, Nova-Lamperti E.

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Cohort Profile: The Cohorts Consortium of Latin America and the Caribbean (CC-LAC)

Cohorts Consortium of Latin America and the Caribbean (CC-LAC).

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Abortion legislation, maternal healthcare, fertility, female literacy, sanitation, violence against women and maternal deaths: a natural experiment in 32 mexican states

Koch E, Chireau M, Pliego F, Stanford J, Haddad S, Calhoun B, Aracena P, Bravo M, Gatica S, Thorp J.

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The Epidemiology of Abortion And Its Prevention in Chile

Koch E.

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[Influence of psychosocial factors on adherence to antihypertensive drug therapy: results from a Cardiovascular Health Program cohort followed in the Metropolitan Region of Santiago, Chile]

Sandoval D, Chacón J, Muñoz R, Henríquez O, Koch E, Romero T.

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Women’s education level, contraceptive use and maternal mortality estimates

Koch E, Calhoun B, Aracena P, Gatica S, Bravo M.

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Impact of reproductive laws on maternal mortality: the chilean natural experiment

Koch E.

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Maternal health consensus for chile in the new millennium

González R, Koch E, Poblete J, Vera C, Muñoz H, Carroli G, Abalos E, Lalonde A, Oyarzún E, Germain A, Schnapp C, Neira J, Hasbun J, Carvajal J, Theodor M, Vargas P, Insunza A, Kusanovic J, Gómez R, González M, Guzmán E, Paublo M, Burgos S, Clavero M, Klassen F.

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Fundamental discrepancies in abortion estimates and abortion-related mortality: a reevaluation of recent studies in mexico with special reference to the international classification of diseases

Koch E, Aracena P, Gatica S, Bravo M, Huerta-Zepeda A, Calhoun B.

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[Methodological flaws on abortion estimates for Latin America: authors' reply to Singh and Bankole]

Koch E, Aracena P, Bravo M, Gatica S, Stecher J, Valenzuela S, Ahlers I.

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Overcoming barriers in the management of hypertension: the experience of the cardiovascular health program in chilean primary health care centers

Sandoval D, Bravo M, Koch E, Gatica S, Ahlers I, Henríquez O, Romero T.

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[Overestimation of the ocurrence of induced abortions in Colombia and other Latinoamerican countries]

Koch E, Bravo M, Gatica S, Stecher J, Aracena P, Valenzuela S, Ahlers I.

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Women’s education level, maternal health facilities, abortion legislation and maternal deaths: a natural experiment in chile from 1957 to 2007

Koch E, Thorp J, Bravo M, Gatica S, Romero C, Ahlers H.

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Early life and adult socioeconomic influences on mortality risk: preliminary report of a ‘pauper rich’ paradox in a chilean adult cohort

Koch E, Romero T, Romero C.X, Aguilera H, Paredes M, Vargas M, Ahumada C.

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Impact of education, income and chronic disease risk factors on mortality of adults: does ‘a pauper-rich paradox’ exist in latin american societies?

Koch E, Romero T, Romero C.X, Akel C, Manríquez L, Paredes M, Román C, Taylor A, Vargas M, Kirschbaum A.

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Impact of parity on anthropometric measures of obesity controlling by multiple confounders: a cross-sectional study in chilean women

Koch E, Bogado M, Araya F, Romero T, Díaz C, Manriquez L, Paredes M, Román C, Taylor, Kirschbaum A.

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Socioeconomic and educational inequities as independent predictors for mortality in a developing country. A cohort study in San Francisco, Chile

Koch E, Romero T, Manríquez L, Paredes M, Ortúzar E, Taylor A, Román C, Kirschbaum A, Díaz C.

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Popperian epidemiology and the logic of bi-conditional modus tollens arguments for refutational analysis of randomised controlled trials

Koch E, Otarola A, Romero T, Kirschbaum A, Ortuzar E.

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A landmark for popperian epidemiology: refutation of the randomised aldactone evaluation study

Koch E, Otarola A, Kirschbaum A.

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[Predictors of non fatal cardiovascular events in a Chilean cohort: results of the San Francisco Project]

Koch E, Otárola A, Manríquez L, Kirschbaum A, Paredes M, Silva C.

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ARTÍCULOS DE INVESTIGACIÓN

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Archivo

Enriqeuz Y, Critto M, Weinberg R, De Janon L, Galleguillos A, Koch E.

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Muñoz-Grez C, Vidal M, Rojas T, Ferrada L, Zuñiga F, Vera A, Sanhueza S, Quiroga R, Cabrera C, Antilef B, Cartes R, Acevedo M, Fraga M, Alarcón-Zapata P, Hernández M, Salas-Burgos A, Tapia-Belmonte F, Yáñez M, Riquelme E, González W, Rivera C, Oñate A, Lamperti L, Nova-Lamperti E.

Echeverría-Bugueño M, Hernández M, Avendaño-Herrera R.

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Garcés-Parra C, Saldivia P, Hernández M, Uribe E, Román J, Torrejón M, Gutiérrez J, Cabrera-Vives G, García-Robles M, Aguilar W, Soto M, Tarifeño-Saldivia E.

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Avendaño-Herrera R, Echeverría-Bugueño M, Hernández M, Saldivia P, Irgang R.

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Yañez A, Barrientos C, Isla A, Aguilar M, Flores-Martin S, Yuivar Y, Ojeda A, Ibieta P, Hernández M, Figueroa J, Avendaño-Herrera R, Mancilla M.

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